The Britain-based Syrian Observatory for Human Rights says it has recorded the deaths of 353,935 people since the conflict began with anti-government protests in March 2011.
Those killed included 106,390 civilians, of whom 19,811 were children and 12,513 were women, according to a toll it released on March 12, 2018.
In a country with a pre-war population of 23 million, the United Nations estimates that 6.1 million people have been internally displaced by the fighting.
Handicap International, a French non-governmental organisation, says one million people have been wounded in the war.